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re: Will GLP-1s end extreme obesity?

Posted on 11/14/25 at 12:50 pm to
Posted by RogerTheShrubber
Juneau, AK
Member since Jan 2009
298305 posts
Posted on 11/14/25 at 12:50 pm to
No, because people will adjust and in several years gain the weight back.

Posted by CatfishJohn
Member since Jun 2020
19444 posts
Posted on 11/14/25 at 12:51 pm to
quote:

I think the bigger question is when will Uncle Sam subsidize it so that not being fat is only for the elite. Them shots are expensive.

Also, this is how I Am Legend begins.


I think the future pricing will be extremely low with generics.
Posted by TigerFanatic99
South Bend, Indiana
Member since Jan 2007
35394 posts
Posted on 11/14/25 at 1:02 pm to
quote:

I think the future pricing will be extremely low with generics


Don't those patents last 20 years or something like that, though?
Posted by LSUAlum2001
Stavro Mueller Beta
Member since Aug 2003
48256 posts
Posted on 11/14/25 at 1:07 pm to
quote:

This simply isn't true. People may gain weight back if they continue bad eating habits, but its not due to the shot.


That’s his reasoning.

Most will not have changed their habit and will go back to being fat.
Posted by lsu777
Lake Charles
Member since Jan 2004
37304 posts
Posted on 11/14/25 at 1:07 pm to
quote:

Just like mRNA vaccines



lets see....mrna tells cells to produce a protein vs raising the levels of a naturally occurring hormone that is suppressed in obese individuals

i know you are being a contrarian just to be one because i know you are smart enough to actually read and research them

taking a glp-1 would be more like taking TRT if your levels are naturally low

stop trying to aggravate me on a friday
Posted by Mingo Was His NameO
Brooklyn
Member since Mar 2016
37536 posts
Posted on 11/14/25 at 1:09 pm to
quote:

i know you are being a contrarian just to be one because i know you are smart enough to actually read and research them


I’m just trying to figure out when we trust and don’t trust big pharma
Posted by lsu777
Lake Charles
Member since Jan 2004
37304 posts
Posted on 11/14/25 at 1:11 pm to
quote:

That’s his reasoning.

Most will not have changed their habit and will go back to being fat.



why would one not go down to basic maintenance dose instead of getting off completely?

especially considering the extreme amount of health benefits not related to the obesity itself?


and you of all people should be sympathetic to its use considering many many bodybuilders are using it. tons of them are on trizepitide + GH + trt as their basic maintenance stack.
Posted by GreatLakesTiger24
Member since May 2012
59571 posts
Posted on 11/14/25 at 1:11 pm to
knowing stuff about ozempic and the other drugs is trashy
Posted by Mingo Was His NameO
Brooklyn
Member since Mar 2016
37536 posts
Posted on 11/14/25 at 1:12 pm to
quote:

and you of all people should be sympathetic to its use considering many many bodybuilders are using it. tons of them are on trizepitide + GH + trt as their basic maintenance stack.


Those the same dudes that die in their 40s right?
Posted by lsu777
Lake Charles
Member since Jan 2004
37304 posts
Posted on 11/14/25 at 1:12 pm to
quote:

I’m just trying to figure out when we trust and don’t trust big pharma


i only trust when the studies, the actually data used in the studies and i can verify

everyone else can do what ever they want to do and trust who they want to trust
Posted by ssand
the Rez
Member since Mar 2004
1580 posts
Posted on 11/14/25 at 1:13 pm to
quote:

Will GLP-1s end extreme obesity?


It's probably going to end a lot more than that
Posted by lsu777
Lake Charles
Member since Jan 2004
37304 posts
Posted on 11/14/25 at 1:14 pm to
quote:

Those the same dudes that die in their 40s right?


no

and considering glp-1 and especially gen 2 and 3 have been shown to promote heart health and lower all cause mortality....i would say the glp1 would be helping.

but keep being a contrarian...dick
Posted by lsu777
Lake Charles
Member since Jan 2004
37304 posts
Posted on 11/14/25 at 1:15 pm to
quote:


knowing stuff about ozempic and the other drugs is trashy


touche.

good to know science is trashy
Posted by Mingo Was His NameO
Brooklyn
Member since Mar 2016
37536 posts
Posted on 11/14/25 at 1:17 pm to
quote:

but keep being a contrarian...dick


I’m merely pointing out that this “medicine” is following the same talking points of many medicines and therapies, such as OxyContin and mRNA vaccines, before it.

Is it a miracle drug? I suppose it could be. But OxyContin was going to change the world and end pain too. The one thing we know for sure is somebody is going to get rich whether it works or not.
Posted by Powerman
Member since Jan 2004
172179 posts
Posted on 11/14/25 at 1:21 pm to
quote:


and considering glp-1 and especially gen 2 and 3 have been shown to promote heart health and lower all cause mortality....i would say the glp1 would be helping.


I think the concern with GLP-1 drugs is getting off of them completely and not making lifestyle changes. Sarcopenia is probably the biggest concern for people that have lost weight aided with these drugs.
Posted by lsu777
Lake Charles
Member since Jan 2004
37304 posts
Posted on 11/14/25 at 1:28 pm to
quote:

I’m merely pointing out that this “medicine” is following the same talking points of many medicines and therapies, such as OxyContin and mRNA vaccines, before it.

Is it a miracle drug? I suppose it could be. But OxyContin was going to change the world and end pain too. The one thing we know for sure is somebody is going to get rich whether it works or not.


not really. I mean glp-1 was around for a long time, just being used for diabetics but for some reason media latched on to it being good for weight loss because some celebrities were using it and suddenly it blew up.

its just a peptide and i mean if being honest it was discovered in the ealy 80s and had plenty of studies showing it was useful for treating type 2. they studied it for 2 decades before it came to market for type 2.

then over another decade of use and study before approved for weight loss. mianly after it was discovered that glp-1 naturally was suppressed in overweight individuals. we still dont know why they are suppressed, could be bodies natural reaction to over riding the signal over and over or could be an issue with output. IMO fat people over ride the signal until the body says frick it, but thats just my opinion.


i mean its not addicting. its naturally occurring in the body, the are very good for the heart, good for insulin sensitivity, blood sugar levels, all cause mortality and help with addiction.

the thing is the medicine is designed to punish you if you act like an a-hole.....want to go out and stuff your face full of fatty and highly processed foods...it will make you sick AF. this is where you hear many of the horror stories.
Posted by lsu777
Lake Charles
Member since Jan 2004
37304 posts
Posted on 11/14/25 at 1:28 pm to
quote:

I think the concern with GLP-1 drugs is getting off of them completely and not making lifestyle changes. Sarcopenia is probably the biggest concern for people that have lost weight aided with these drugs



i agree with that. cant help dumbass people. they are going to do dumbass things.
Posted by LSUAlum2001
Stavro Mueller Beta
Member since Aug 2003
48256 posts
Posted on 11/14/25 at 1:39 pm to
..because people know what they need to do now to start down the path to a healthier lifestyle but they have chosen not to do it. They choose the quick fix, not the long, hard road to achieve it; which is why it’s easier to fall back to where they were to start when they stop taking it.

Sure, some will make the necessary changes to live healthier without it, but I fear most will not.
.
This post was edited on 11/14/25 at 2:01 pm
Posted by eatpie
Kentucky
Member since Aug 2018
1583 posts
Posted on 11/14/25 at 1:39 pm to
quote:

we know the long term effects considering they have been around for 2 decades and GLP-1 is a natural hormone that is already in the body. its just a peptide

god damn some of you are stupid AF


Then there's this goober...

who simply doesn't understand (or hasn't read) the medical history of these drugs. The long term effects for weight reduction in the morbidly obese has not been studied specifically, and these are the people receiving the shots.

Posted by Mingo Was His NameO
Brooklyn
Member since Mar 2016
37536 posts
Posted on 11/14/25 at 1:40 pm to
quote:

not the long, hard road to achieve it;


It’s not hard at all
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