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Started By
Message
Veterinarians…a Question About Nsaid Poisoning for Dogs.UPDATE…death was caused by Rimadyl
Posted on 10/19/24 at 7:46 pm
Posted on 10/19/24 at 7:46 pm
Can 150 mg per day of Rimadyl cause liver and kidney failure in a 65 pound dog ? Administered over two and a half days prior to organ failure. TIA
This post was edited on 11/24/24 at 7:38 am
4
Posted on 10/19/24 at 8:09 pm to OTIS2
I’m not a vet but my vet did say that there is a concern for prolonged use vs galliprant.
How many doses were administered? They gave my 68 lb lab 100 mg after his surgery, so 150 seems a little high.
What I really came here to say is you might get more vet response on the OT.
How many doses were administered? They gave my 68 lb lab 100 mg after his surgery, so 150 seems a little high.
What I really came here to say is you might get more vet response on the OT.
Posted on 10/19/24 at 8:12 pm to Theduckhunter
Thx. I’ll post on the OT, too.
The administration was 75 mg twice a day. 5 doses were given before discontinuation.
The administration was 75 mg twice a day. 5 doses were given before discontinuation.
Posted on 10/19/24 at 8:21 pm to OTIS2
Ok. I just looked back and his dosage was 1.5 tablets so he was getting 150 mg/day.
Posted on 10/19/24 at 8:25 pm to Theduckhunter
Were the tablets 75 mg or 100mg?
Posted on 10/19/24 at 8:29 pm to OTIS2
100 mg tablets, 1.5 tablets once daily.
Posted on 10/20/24 at 3:38 pm to OTIS2
It shouldn’t unless dog had underlying kidney or liver issues. Dose for 65# dog would be 130mg. A lot would go 1 1/4 tabs but many vets will round up. How old is dog and had there been any previous bloodwork.
Posted on 10/20/24 at 5:52 pm to LSUVET82
Thanks. I started a thread on the OT to get more exposure. I’ve posted info there. I’ll copy and paste here. Thx
My other information
Thanks for the reply. My goal is to understand why the dog died.We’re waiting on the necropsy results.
He was 11.5 years old. His bloodwork was good leading in to this treatment. All normal in early September preparing to report for daily radiation to treat a recurrent grade 2 sarcoma on the right front leg that we couldn’t eradicate with surgery.
He was on no medication. He was very active. No arthritis. Had good hearing and sight. Still an excellent hunter.No prior disease.
I’ll post his pre admission workup.
quote:
Information CBC: No clinically significant abnormalities Chemistry: Mild, static elevation in ALT; otherwise no clinically significant abnormalities Cytology (right antechbrial mass): Soft tissue sarcoma Chest radiographs: No evidence of metastasis, otherwise unremarkable Abdominal ultrasound: ??Nodular hyperechoic hepatopathy may represent vacuolar hepatopathy, regeneration, nodular hyperplasia, hepatitis, or neoplasia. ??Heterogeneous splenomegaly has differentials of sedation, lymphoid hyperplasia, splenitis, or infiltrative neoplasia. ??Mild bilateral adrenomegaly may be a normal variant and measuring artefact due to panting, may represent benign hyperplasia, or may represent hyperadrenocorticism. : Benign prostatic hyperplasia with small prostatic cysts. Intact male status. Mild bilateral chronic nephropathy and nephrocalcinosis
He was sailing through the radiation treatment without any complications. The nsaid treatment began Friday evening. He stopped eating Sunday, I think. By Tuesday he’s in ICU with highly elevated liver values. Downhill quickly from there.
My other information
Thanks for the reply. My goal is to understand why the dog died.We’re waiting on the necropsy results.
He was 11.5 years old. His bloodwork was good leading in to this treatment. All normal in early September preparing to report for daily radiation to treat a recurrent grade 2 sarcoma on the right front leg that we couldn’t eradicate with surgery.
He was on no medication. He was very active. No arthritis. Had good hearing and sight. Still an excellent hunter.No prior disease.
I’ll post his pre admission workup.
quote:
Information CBC: No clinically significant abnormalities Chemistry: Mild, static elevation in ALT; otherwise no clinically significant abnormalities Cytology (right antechbrial mass): Soft tissue sarcoma Chest radiographs: No evidence of metastasis, otherwise unremarkable Abdominal ultrasound: ??Nodular hyperechoic hepatopathy may represent vacuolar hepatopathy, regeneration, nodular hyperplasia, hepatitis, or neoplasia. ??Heterogeneous splenomegaly has differentials of sedation, lymphoid hyperplasia, splenitis, or infiltrative neoplasia. ??Mild bilateral adrenomegaly may be a normal variant and measuring artefact due to panting, may represent benign hyperplasia, or may represent hyperadrenocorticism. : Benign prostatic hyperplasia with small prostatic cysts. Intact male status. Mild bilateral chronic nephropathy and nephrocalcinosis
He was sailing through the radiation treatment without any complications. The nsaid treatment began Friday evening. He stopped eating Sunday, I think. By Tuesday he’s in ICU with highly elevated liver values. Downhill quickly from there.
This post was edited on 10/20/24 at 6:48 pm
Posted on 10/20/24 at 6:34 pm to OTIS2
Based on the info provided and assuming your dog had not had an adverse reaction to similar medications in the past, the treatment plan your vet put in place seems appropriate. MAYBE a little high when you consider age, but within tolerance. Could carprofen at that dosage cause multi-organ failure in 60 hours? It's possible, but would be incredibly rare for a dog to have that severe of a reaction that quickly. Unfortunately some dogs (like humans) will have unpredictable reactions to medication. Given your dog's age and medical condition, if I had to guess, there likely was something else going on that the tests missed that contributed to liver/organ failure.
Really sorry for your loss. Its never easy, especially like this
Really sorry for your loss. Its never easy, especially like this
Posted on 10/20/24 at 6:42 pm to The Nino
Thanks. We were looking forward to another duck and goose season. He was a great retriever. And an awesome camp companion.
Posted on 10/20/24 at 6:53 pm to OTIS2
quote:
elevation in ALT
Seems like this would have something to do with it.
Posted on 10/20/24 at 7:15 pm to diat150
Possibly so. Thx
Posted on 10/20/24 at 7:16 pm to diat150
Nm
This post was edited on 10/20/24 at 7:54 pm
Posted on 11/24/24 at 7:36 am to OTIS2
UPDATE…necropsy confirmed death was due to liver injury caused by Rimadyl administration. Beware of this drug. It’s characterized as an idiosyncratic injury.
Posted on 11/24/24 at 7:53 am to OTIS2
No idea what any of those meds are or what they treat but man that’s gotta suck.
Posted on 11/24/24 at 8:15 am to WillFerrellisking
Sucks really bad. He was a fantastic retriever, but an even better friend. He was ready to hunt a few more years. Hate it.
Posted on 11/24/24 at 9:53 am to OTIS2
Had your dog ever been given rimadyl before?
I ask because both of my dogs have taken it before without ill effects, but one of them is getting up there in age.
I ask because both of my dogs have taken it before without ill effects, but one of them is getting up there in age.
Posted on 11/24/24 at 10:39 am to Theduckhunter
I do not know the answer for that. I will speak to my vet next week. I will definitely ask the question. I sent the necropsy report to them Friday.
He had undergone three very minor surgeries in the last two years to remove the sarcoma for which he was undergoing radiation treatment. I may have been given Rimadyl then.
He had undergone three very minor surgeries in the last two years to remove the sarcoma for which he was undergoing radiation treatment. I may have been given Rimadyl then.
Posted on 11/26/24 at 5:28 am to Theduckhunter
Spoke with my vet. She used Rimadyl in lower doses safely after each of his prior sarcoma removal procedures(3). I believe the elevated dosage was the causative factor. I do not believe there was a reason to give him 150mgs.
Posted on 11/26/24 at 2:47 pm to OTIS2
The dosage is 1 mg of Rimadyl per lb every 12 hours or 2 mg once daily.
If the dog has tested to have preexisting liver dysfunction dosage should be less..
If the dog has tested to have preexisting liver dysfunction dosage should be less..
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