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re: Where are we with Hydroxychloroquine?
Posted on 3/28/20 at 9:59 pm to LSUGrrrl
Posted on 3/28/20 at 9:59 pm to LSUGrrrl
quote:Bayer offered Resochin, which is chloroquine phophate, basically a different derivative of chloroquine as opposed to hydroxychloriquine. as said Bayer's cp is not approved in the US but there was at least one version of it that was approved for another company but it was discontinued mostly bc there wasn't much of a market for it.
I thought Bayer promised millions of doses to the US.
0
Posted on 3/28/20 at 10:28 pm to ConwayGamecock
quote:
He is obviously referring to the couple that ingested it: the man died, the woman survived. Hence, a 50% chance that you will die......
You mean the stupid frickers that took aquarium cleaner? Which is not the same as hydroxychloroquine...
Posted on 3/28/20 at 10:30 pm to AubieinNC2009
quote:I think they should pound sand in prison.
I think these dem govs that are banning it should be told to pound sand
Posted on 3/28/20 at 10:34 pm to Little Trump
You need to know someone on the Texas Medical Board or be Tom Hanks to get it. Otherwise they may give you some when it is too late and you are on the vent.
Posted on 3/28/20 at 10:38 pm to beezy
quote:
Just saw a tweet that said New York has banned the use other than clinical trials.
They are banning it bc there is limited supply. Then they get to choose who gets it. It’ll be mostly well connected people and people that are too far gone.
Posted on 3/28/20 at 10:41 pm to ConwayGamecock
quote:
He is obviously referring to the couple that ingested it: the man died, the woman survived.
Correct. I thought the part about 50% survival rate would be the clue.
Posted on 3/28/20 at 10:47 pm to timdonaghyswhistle
quote:
Abstract We need an effective treatment to cure COVID-19 patients and to decrease the virus carriage duration. In 80 in-patients receiving a combination of hydroxychloroquine and azithromycin we noted a clinical improvement in all but one 86 year-old patient who died, and one 74 year- old patient still in intensive care unit. A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly de discharge from highly contagious wards with a mean length of stay of five days. We believe other teams should urgently evaluate this cost-effective therapeutic strategy, to both avoid the spread of the disease and treat patients as soon as possible before severe respiratory irreversible complications take hold.
One study out
LINK
This post was edited on 3/28/20 at 10:51 pm
Posted on 3/29/20 at 1:47 am to supatigah
quote:
On Friday on Rush’s show they said Israel is sending 4 million doses to the US with 6 million more to come
There is a US company that is making 30 or 40 million chloroquine too.
Posted on 3/29/20 at 8:16 am to shell01
quote:
Results: We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro.
LINK
The six articles are there at the link.
quote:
Conclusion Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.
quote:
Patients and methods French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.
LINK
A lot of other articles here:
LINK
Posted on 3/29/20 at 8:48 am to Mid Iowa Tiger
Why didn't you quote the Conclusion of the review article you posted?
I completely agree with the above. We should not be rushing to call this the cure, we should be completing high-quality clinical trials (which, by the way, we are.)
Most of the "articles" you pointed me to are in-vitro or theoretical, discussing possible MOA. That's great, I don't disagree that's there's a valid rationale here. But when people start saying "90% cure rate!!!" without actually reading and understanding the study and endpoints, it's frustrating.
I've been running critical care clinical research trials for almost 20 years. The studies published to date show promise that HCQ + A may reduce the viral load of mild cases. That could be used to reduce the spread of disease (or time needed to quarantine.) There's no data to date that this actually improves clinical outcomes.
quote:
Conclusions: There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed.
I completely agree with the above. We should not be rushing to call this the cure, we should be completing high-quality clinical trials (which, by the way, we are.)
Most of the "articles" you pointed me to are in-vitro or theoretical, discussing possible MOA. That's great, I don't disagree that's there's a valid rationale here. But when people start saying "90% cure rate!!!" without actually reading and understanding the study and endpoints, it's frustrating.
I've been running critical care clinical research trials for almost 20 years. The studies published to date show promise that HCQ + A may reduce the viral load of mild cases. That could be used to reduce the spread of disease (or time needed to quarantine.) There's no data to date that this actually improves clinical outcomes.
Posted on 3/29/20 at 9:28 am to shell01
Let’s guess that you have TDS, and like the MSM and the Democratic leadership, would be more than happy to drag out this crisis and watch more Americans die.
Posted on 3/29/20 at 9:39 am to shell01
1100 started treatment with Hydroxychloroquine + A last week in NY and those results should trickle in early this week
Would 1100 be an acceptable study?
Would 1100 be an acceptable study?
Posted on 3/29/20 at 9:47 am to Aldo
Had a good friend's mother who is in Ochsner in ICU take the combo drugs. She started feeling better. The Media is riddled with TDS and would use us as collateral damage gleefully to get orange man bad.
Posted on 3/29/20 at 9:48 am to shell01
quote:
+ A may reduce the viral load of mild cases.
Strongly disagree. It’s not just mild cases where the combo is making a difference. In fact, most cases where this is getting applied is the extreme “nothing left to lose” cases.
In normal, new drug circumstances I agree careful study is warranted. These are not normal circumstances. Even if the efficacy is 50% we should be throwing everything we have at this disease. Furthermore, we should be doing so while working to get our country back to normal.
More people are being harmed by the economic impact of our actions than this disease. It’s like saying by killing the patient you have cured their cancer.
Posted on 3/29/20 at 9:48 am to Little Trump
My mom has a stockpile of it (autoimmune treatment).
Posted on 3/29/20 at 9:59 am to Little Trump
quote:
Would 1100 be an acceptable study?
It's not only about the n but the study design. Who is being treated? What is being measured? Is there a control group? But yes, obviously 1100 is more compelling than 20.
Posted on 3/29/20 at 10:02 am to Mid Iowa Tiger
quote:
Strongly disagree. It’s not just mild cases where the combo is making a difference. In fact, most cases where this is getting applied is the extreme “nothing left to lose” cases.
In reported studies? Wrong. Anecdotally in practice, possibly.
Looking forward to seeing the data.
Posted on 3/29/20 at 10:03 am to Little Trump
Only thing that has me curious is that the death numbers keep rising. If it was working, I'd expect that to, in large part, stop...assuming the most dire are being treated. Otherwise I am encouraged and hopeful....
Posted on 3/29/20 at 10:05 am to Little Trump
It along with Zinc has been confirmed to be the treatment. Libs don’t want you to figure that out so they are trying to block it from being prescribed.
Posted on 4/1/20 at 7:17 am to GetmorewithLes
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